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Moradec LLC由Helen（Hongyuan）Mao博士于2012年創(chuàng)立，主要目標(biāo)是為快速和經(jīng)濟(jì)的抗體 - 藥物結(jié)合物發(fā)現(xiàn)提供新穎的研究工具。毛博士擁有超過(guò)14年的工業(yè)研發(fā)經(jīng)驗(yàn)，包括主要制藥公司，中小型生物技術(shù)公司。她近擔(dān)任Fabrus的科學(xué)官，這是開(kāi)發(fā)Fabrus Arrayed抗體篩選技術(shù)的關(guān)鍵。除了廣泛的抗體優(yōu)化專業(yè)知識(shí)外，她還積累了基于表皮生長(zhǎng)因子受體的抗體治療方法的豐富知識(shí)。在Fabrus之前，Mao博士領(lǐng)導(dǎo)了Biosite（現(xiàn)為Alere）抗體開(kāi)發(fā)的蛋白質(zhì)純化組，先進(jìn)的診斷公司，擁有用于開(kāi)發(fā)診斷抗體的噬菌體展示平臺(tái)技術(shù)。在Ansata Therapeutics，毛博士發(fā)明了基于分選酶的新型酶促蛋白質(zhì)結(jié)合方法，該方法已經(jīng)獲得了研究應(yīng)用，用于細(xì)胞表面標(biāo)記，蛋白質(zhì)陣列，核磁共振和蛋白質(zhì) - 藥物結(jié)合等。毛醫(yī)生進(jìn)行了她的博士后諾華研究基金會(huì)（GNF）雅培實(shí)驗(yàn)室和基因組研究所的研究。她在麻省理工學(xué)院獲得生物化學(xué)博士學(xué)位，在北京大學(xué)獲得化學(xué)學(xué)士學(xué)位。毛在諾華研究基金會(huì)（GNF）的雅培實(shí)驗(yàn)室和基因組研究所進(jìn)行了博士后研究。她在麻省理工學(xué)院獲得生物化學(xué)博士學(xué)位，在北京大學(xué)獲得化學(xué)學(xué)士學(xué)位。毛在諾華研究基金會(huì)（GNF）的雅培實(shí)驗(yàn)室和基因組研究所進(jìn)行了博士后研究。她在麻省理工學(xué)院獲得生物化學(xué)博士學(xué)位，在北京大學(xué)獲得化學(xué)學(xué)士學(xué)位。
Moradec Fab-αHFc-NC-MMAF說(shuō)明書(shū)
具有不可切割接頭的Fab抗人IgG Fc-MMAF抗體 | 目錄編號(hào)：AH-201-AF |
Fab-αHFc-NC-MMAF是與具有不可切割接頭的單甲基auristatin F（MMAF）綴合的抗人IgG Fc特異性抗體的Fab片段。抗體部分是對(duì)人IgG的Fc區(qū)特異的多克隆抗體Fab片段。單甲基auristatin F（MMAF）是一種細(xì)胞毒性小分子，通過(guò)阻斷微管蛋白的聚合來(lái)抑制細(xì)胞分裂。連接MMAF與抗體的不可切割接頭在細(xì)胞外液中是穩(wěn)定的，但是在進(jìn)入細(xì)胞時(shí)可以通過(guò)未的機(jī)制切割。Fab 2°ADC的單價(jià)性質(zhì)在某些應(yīng)用中可能比全長(zhǎng)IgG 2°ADC具有一些優(yōu)勢(shì)。 | |
Moradec的新型二抗 - 藥物偶聯(lián)物（2°ADC）是預(yù)先篩選抗體導(dǎo)聯(lián)作為ADC候選物的重要研究工具。“他們工作非常出色，而且沒(méi)有主要的ab，它們的毒性極低！ |
具有可切割接頭的IgGs抗人IgG Fc-PBD抗體
具有可切割接頭的IgGs抗小鼠IgG Fc-PBD抗體
具有可切割接頭的IgG抗兔IgG（H + L）-PBD抗體
IgGs Anti-Human IgG (Fc Specific) ADCs
Product Name | Description | Catalog No | QTY | Price |
αHFc-NC-MMAF | IgGs Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker | AH-101AF-50 | 50µg | $330 |
AH-101AF-20 | 20µg | $165 | ||
αHFc-CL-MMAF | IgGs Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker | AH-102AF-50 | 50µg | $330 |
AH-102AF-20 | 20µg | $165 | ||
αHFc-CL-MMAE | IgGs Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker | AH-102AE-50 | 50µg | $330 |
AH-102AE-20 | 20µg | $165 | ||
αHFc-CL-DMSA | IgGs Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker | AH-102DS-50 | 50µg | $330 |
AH-102DS-20 | 20µg | $165 | ||
αHFc-CL-DMDM | IgGs Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker | AH-102DD-50 | 50µg | $330 |
AH-102DD-20 | 20µg | $165 | ||
αHFc-CL-PNU | IgGs Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker | AH-102PN-50 | 50µg | $330 |
AH-102PN-20 | 20µg | $165 | ||
αHFc-NC-DM1 | IgGs Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker | AH-103D1-50 | 50µg | $330 |
AH-103D1-20 | 20µg | $165 | ||
αHFc-CL-PBD | IgGs Anti-Human IgG Fc-PBD Antibody with Cleavable Linker | AH-106PB-50 | 50µg | $330 |
AH-106PB-20 | 20µg | $165 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αHFc-NC-MMAF | Fab Anti-Human IgG Fc-MMAF Antibody with Non-Cleavable Linker | AH-201AF-50 | 50µg | $440 |
AH-201AF-20 | 20µg | $220 | ||
Fab-αHFc-CL-MMAF | Fab Anti-Human IgG Fc-MMAF Antibody with Cleavable Linker | AH-202AF-50 | 50µg | $440 |
AH-202AF-20 | 20µg | $220 | ||
Fab-αHFc-CL-MMAE | Fab Anti-Human IgG Fc-MMAE Antibody with Cleavable Linker | AH-202AE-50 | 50µg | $440 |
AH-202AE-20 | 20µg | $220 | ||
Fab-αHFc-CL-DMSA | Fab Anti-Human IgG Fc-Duocarmycin SA Antibody with Cleavable Linker | AH-202DS-50 | 50µg | $440 |
AH-202DS-20 | 20µg | $220 | ||
Fab-αHFc-CL-DMDM | Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker | AH-202DD-50 | 50µg | $440 |
AH-202DD-20 | 20µg | $220 | ||
Fab-αHFc-CL-PNU | Fab Anti-Human IgG Fc-PNU159682 Antibody with Cleavable Linker | AH-202PN-50 | 50µg | $440 |
AH-202PN-20 | 20µg | $220 | ||
Fab-αHFc-NC-DM1 | Fab Anti-Human IgG Fc-DM1 Antibody with Non-Cleavable Linker | AH-203D1-50 | 50µg | $440 |
AH-203D1-20 | 20µg | $220 | ||
Fab-αHFc-NC-AAMT | Fab Anti-Human IgG Fc-Amanitin Antibody with Non-Cleavable Linker | AH-20M-50 | 50µg | $440 |
AH-20M-20 | 20µg | $220 |
IgGs Anti-Human IgG (Fab Specific) ADCs
Product Name | Description | Catalog No | QTY | Price |
αHFab-NC-MMAF | IgGs Anti-Human IgG Fab-MMAF Antibody with Nonceavable Linker | AH-121AF-50 | 50µg | $360 |
AH-121AF-20 | 20µg | $180 | ||
αHFab-CL-MMAF | IgGs Anti-Human IgG Fab-MMAF Antibody with Cleavable Linker | AH-122AF-50 | 50µg | $360 |
AH-122AF-20 | 20µg | $180 | ||
αHFab-CL-MMAE | IgGs Anti-Human IgG Fab-MMAE Antibody with Cleavable Linker | AH-122AE-50 | 50µg | $360 |
AH-122AE-20 | 20µg | $180 | ||
αHFab-NC-DM1 | IgGs Anti-Human IgG Fab-DM1 Antibody with Non-Cleavable Linker | AH-123D1-50 | 50µg | $360 |
AH-123D1-20 | 20µg | $180 |
IgGs Anti-Mouse IgG (Fc specific) ADCs
Product Name | Description | Catalog No | QTY | Price |
αMFc-NC-MMAF | IgGs Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker | AM-101AF-50 | 50µg | $374 |
AM-101AF-20 | 20µg | $187 | ||
αMFc-CL-MMAF | IgGs Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker | AM-102AF-50 | 50µg | $374 |
AM-102AF-20 | 20µg | $187 | ||
αMFc-CL-MMAE | IgGs Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker | AM-102AE-50 | 50µg | $374 |
AM-102AE-20 | 20µg | $187 | ||
αMFc-CL-DMSA | IgGs Anti-Mouse IgG Fc-Duocarmycin SA Antibody with Cleavable Linker | AM-102DS-50 | 50µg | $374 |
AM-102DS-20 | 20µg | $187 | ||
αMFc-CL-DMDM | IgGs Anti-Mouse IgG Fc-Duocarmycin DM Antibody with Cleavable Linker | AM-102DD-50 | 50µg | $374 |
AM-102DD-20 | 20µg | $187 | ||
αMFc-CL-PNU | IgGs Anti-Mouse IgG Fc-PNU159682 Antibody with Cleavable Linker | AM-102PN-50 | 50µg | $374 |
AM-102PN-20 | 20µg | $187 | ||
αMFc-NC-DM1 | IgGs Anti-Mouse IgG Fc-DM1 Antibody with Non-Cleavable Linker | AM-103D1-50 | 50µg | $374 |
AM-103D1-20 | 20µg | $187 | ||
αMFc-CL-PBD | IgGs Anti-Mouse IgG Fc-PBD Antibody with Cleavable Linker | AM-106PB-50 | 50µg | $374 |
AM-106PB-20 | 20µg | $187 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αMFc-NC-MMAF | Fab Anti-Mouse IgG Fc-MMAF Antibody with Non-Cleavable Linker | AM-201AF-50 | 50µg | $495 |
AM-201AF-20 | 20µg | $248 | ||
Fab-αMFc-CL-MMAF | Fab Anti-Mouse IgG Fc-MMAF Antibody with Cleavable Linker | AM-202AF-50 | 50µg | $495 |
AM-202AF-20 | 20µg | $248 | ||
Fab-αMFc-CL-MMAE | Fab Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker | AM-202AE-50 | 50µg | $495 |
AM-202AE-20 | 20µg | $248 | ||
Fab-αMFc-CL-DMDM | Fab Anti-Mouse IgG Fc-duocarmycin DM Antibody with Cleavable Linker | AM-202DD-50 | 50µg | $495 |
AM-202DD-20 | 20µg | $248 | ||
Fab-αMFc-NC-DM1 | Fab Anti-Mouse IgG Fc-DM1 Antibody with Noncleavable Linker | AM-203D1-50 | 50µg | $495 |
AM-203D1-20 | 20µg | $248 |
IgGs Anti-Rabbit IgG (Fc Specific) ADCs
Product Name | Description | Catalog No | QTY | Price |
αOFc-NC-MMAF | IgGs Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker | AO-101AF-50 | 50µg | $396 |
AO-101AF-20 | 20µg | $198 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αOFc-NC-MMAF | Fab Anti-Rabbit IgG Fc-MMAF Antibody with Non-Cleavable Linker | AO-201AF-50 | 50µg | $528 |
AO-201AF-20 | 20µg | $264 |
Product Name | Description | Catalog No | QTY | Price |
αOIgG-NC-MMAF | IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker | AO-111AF-50 | 50µg | $396 |
AO-111AF-20 | 20µg | $198 | ||
αOIgG-CL-MMAF | IgGs Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker | AO-112AF-50 | 50µg | $396 |
AO-112AF-20 | 20µg | $198 | ||
αOIgG-CL-MMAE | IgGs Anti-Rabbit IgG(H+L)-MMAE Antibody with Cleavable Linker | AO-112AE-50 | 50µg | $396 |
AO-112AE-20 | 20µg | $198 | ||
αOIgG-CL-PBD | IgGs Anti-Rabbit IgG(H+L)-PBD Antibody with Cleavable Linker | AO-116PB-50 | 50µg | $396 |
AO-116PB-20 | 20µg | $198 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αOIgG-NC-MMAF | Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Non-Cleavable Linker | AO-211AF-50 | 50µg | $528 |
AO-211AF-20 | 20µg | $264 | ||
Fab-αOIgG-CL-MMAF | Fab Anti-Rabbit IgG(H+L)-MMAF Antibody with Cleavable Linker | AO-212AF-50 | 50µg | $528 |
AO-212AF-20 | 20µg | $264 |
IgGs Anti-Rat IgG (Fc Specific) ADCs
Product Name | Description | Catalog No | QTY | Price |
αRFc-NC-MMAF | IgGs Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker | AR-101AF-50 | 50µg | $396 |
AR-101AF-20 | 20µg | $198 | ||
αRFc-CL-MMAF | IgGs Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker | AR-102AF-50 | 50µg | $396 |
AR-102AF-20 | 20µg | $198 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αRFc-NC-MMAF | Fab Anti-Rat IgG Fc-MMAF Antibody with Non-Cleavable Linker | AR-201AF-50 | 50µg | $528 |
AR-201AF-20 | 20µg | $264 | ||
Fab-αRFc-CL-MMAF | Fab Anti-Rat IgG Fc-MMAF Antibody with Cleavable Linker | AR-202AF-50 | 50µg | $528 |
AR-202AF-20 | 20µg | $264 | ||
Fab-αRFc-CL-MMAE | Fab Anti-Rat IgG Fc-MMAE Antibody with Cleavable Linker | AR-202AE-50 | 50µg | $528 |
AR-202AE-20 | 20µg | $264 | ||
Fab-αRFc-CL-DMDM | Fab Anti-Rat IgG Fc-Duocarmycin DM Antibody with Cleavable Linker | AR-202DD-50 | 50µg | $528 |
AR-202DD-20 | 20µg | $264 |
Product Name | Description | Catalog No | QTY | Price |
αRIgG-NC-MMAF | IgGs Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker | AR-111AF-50 | 50µg | $396 |
AR-111AF-20 | 20µg | $198 |
Product Name | Description | Catalog No | QTY | Price |
Fab-αRIgG-NC-MMAF | Fab Anti-Rat IgG(H+L)-MMAF Antibody with Non-Cleavable Linker | AR-211AF-50 | 50µg | $528 |
AR-211AF-20 | 20µg | $264 | ||
Fab-αRIgG-CL-MMAF | Fab Anti-Rat IgG(H+L)-MMAF Antibody with Cleavable Linker | AR-212AF-50 | 50µg | $528 |
AR-212AF-20 | 20µg | $264 |
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